Migraine in China

Migraine is a prevalent and debilitating CGRP-mediated neurological disorder characterized by recurrent attacks lasting four to 72 hours with four classic symptoms, including one-sided, pulsating headaches of moderate or severe pain intensity that are associated with nausea or vomiting, and/or hypersensitivity to light (photophobia) and sound (phonophobia). The World Health Organization’s (WHO) 2015 Global Burden of Disease Study ranks migraine as the third most prevalent disease in the world [1] and the seventh highest specific cause of disability worldwide. Migraine affects approximately 9% of the adult population in China[2], comprising approximately 90 million adults. Approximately 90% of Chinese migraineurs suffer from between one to fourteen headache days per month, and approximately 10% have more than fourteen per month[3]. Approximately 24% of individuals Chinese migraineurs miss more than twenty days of work over a three-month period as a result of migraine [2]. The total indirect cost to Chinese society from lost productivity each year due to migraine is estimated to be about USD$40 billion[2]. Comorbid conditions associated with migraine include depression, anxiety and cardiovascular disease[4].


[1] Disease GBD, Injury I, Prevalence C. Global, regional, and national incidence, prevalence, and years lived with disability for 328 diseases and injuries for 195 countries, 1990-2016: a systematic analysis for the Global Burden of Disease Study 2016. Lancet.2017;390(2017):1211–59.
[2] Yu, S., et al., The prevalence and burden of primary headaches in China: a population-based door-to-door survey. Headache, 2012. 52 (4): p. 582-91.
[3] Liu, R., et al., Health-care utilization for primary headache disorders in China: a population-based door-to-door survey. J Headache Pain, 2013. 14: p. 47.
[4] Buse, D.C., M.F. Rupnow, and R.B. Lipton, Assessing and managing all aspects of migraine: migraine attacks, migraine-related functional impairment, common comorbidities, and quality of life. Mayo Clin Proc, 2009. 84 (5): p. 422-35. [7] 国际头痛分类第三版